Formaldehyde is used in pressed-wood building materials, fungicides, germicides, disinfectants, and certain preservatives. Repeated exposure to formaldehyde can possibly lead to cancer. Formaldehyde. 4 Formaldehyde exposure may cause eye irritation. Most formaldehyde produced in the United States is for the manufacture of resins, such as urea-formaldehyde, used to make the adhesives for pressed wood products, such as particleboard, furniture, paneling, cabinets, and other products. The bronchoconstrictive effects of formaldehyde exposure may be partially responsible for the lower airway discom fort reported in the study upon which the 8-hour and chronic RELs are based. This aldehyde is a well‐established neurotoxin that affects memory, learning, and behavior. OSHA Fact Sheet, (April 2011). According to the United States Environmental Protection Agency (EPA), formaldehyde is a colorless, flammable, and strong-smelling chemical. Health Effects of Formaldehyde Formaldehyde can cause irritation of the skin, eyes, nose, and throat. You should not consider the information in this site to be specific, professional medical advice for your personal health or for your family's personal health. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. It is commonly used in producing household products, such as adhesives, coatings, dishwashing liquids, fabric softener, glues and paper products. The NIOSH Pocket Guide to Chemical Hazards (NPG) helps workers, employers, and occupational health professionals recognize and control workplace chemical hazards. The level of exposure depends upon the dose, duration, and work being done. Learn more from the Agency for Toxic Substances and Disease Registry about the health effects of formaldehyde exposure. Materials in this section are updated as new information and vaccines become available. You will be subject to the destination website's privacy policy when you follow the link. Preservatives used in some medicines and cosmetics may contain formaldehyde. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Children’s Hospital of Philadelphia is a charitable 501(c)(3) nonprofit organization. There are limited data available on the direct effects of exposure to formaldehyde during pregnancy. 88): Formaldehyde, IARC Monograph (Vol. Formaldehyde is toxic over a range of doses; chances of exposure and subsequent harmful effects are increased as (room) temperature increases, because of FA's volatility. Formaldehyde can cause irritation of the eyes, nose, and throat and neurological effects. In significant doses, the chemical is a neurotoxin. What are some side effects that I need to call my doctor about right away? WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Visit NIOSH’s page on Managing Chemical Safety in the Workplace to learn more about controlling chemical workplace exposures. ; It is used to treat odor and very bad sweating of the feet. Therefore, is not possible to draw any definitive conclusions. It is used in the production of fertilizer, paper, plywood, and some resins. Formaldehyde is used in many industries. You should not use it to replace any relationship with a physician or other qualified healthcare professional. It is used in the production of fertilizer, paper, plywood, and some resins. Human and animal studies indicate that formaldehyde, at certain exposure levels, can be irritating to the upper respiratory tract and eyes with inhalation exposure, to the skin with dermal exposure, and to the gastrointestinal tract with oral exposure. Centers for Disease Control and Prevention. Following a single intramuscular dose of 200 micrograms of formaldehyde, which is equivalent to the amount of formaldehyde received from DTaP, Hib, IPV, and hepatitis B at a single office visit, formaldehyde was completely removed from the site of injection within 30 minutes. Formaldehyde (and closely related formalin and glutaraldehyde) is an organic chemical usually used in a water solution as a preservative and disinfectant. Formaldehyde, a major component in embalming fluid, is legal to purchase and possess and has become popular due to its euphoric properties. A medical review notes it’s been linked to a higher risk of cancers of the nose and the blood cancer leukemia. The major toxic effects caused by acute formaldehyde exposure via inhalation are eye, nose, and throat irritation and effects on the nasal cavity. The minimal concentration of formaldehyde that can be detected by odor is similar to the level that produces minimal irritant effects on the eyes and in the pulmonary airway, thereby serving as a warning of exposure to the compound. Find patient medical information for Formaldehyde on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Formaldehyde irritates the nose, eyes, and throat. These irritations can happen at low levels of formaldehyde, especially in people who are especially sensitive to the odors. Formaldehyde is Formaldehyde is known to cause cancer Working with formaldehyde may increase your chances of having fertility problems or a miscarriage If you work in an industry that uses formaldehyde, please read chemical labels and the accompanying Safety Data Sheet for hazard information. Although the short-term health effects of formaldehyde exposure are well known, less is known about its potential long-term health effects. Acute exposure is highly irritating to the eyes, nose, andthroat and can make anyone exposed cough andwheeze. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. Assuming an average weight of a 2-month-old of 5 kg and an average blood volume of 85 ml per kg, the total quantity of formaldehyde found in an infant's circulation would be about 1.1 mg, a value about 1,500 times more than the amount an infant would be exposed to in any individual vaccine. For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult your physician or, in serious cases, seek immediate assistance from emergency personnel. Formaldehyde exposure is toxic to the brains of mammals, but the mechanism remains unclear. The NIOSH Manual of Analytical Methods (NMAM) is a collection of methods for sampling and analysis of contaminants in workplace air, and in the blood and urine of workers who are occupationally exposed. Why should I be concerned about exposure to formaldehyde? This finding raised the question of whether formaldehyde exposure could also cause cancer in humans. Provides information on the harmful effects of formaldehyde on workers and how employers can protect them. Concerns about safety have focused on formaldehyde in part because high concentrations of formaldehyde can damage DNA (the building block of genes) and cause cancerous changes in … Other effects seen from exposure to high levels of formaldehyde in humans are coughing, wheezing, chest pains, and bronchitis. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Subsequent exposure may cause severeallergic reactions of the skin, eyes and respiratorytract. Search the HHE database for more information on chemical topics. Havrix: ≤ 0.05 mg (pediatric), ≤ 0.1 mg (adult), Vaqta: 0.0004 mg (pediatric), 0.0008 mg (adult), Menactra®  quantity per dose: < 0.00266 mg, ©2020 The Children’s Hospital of Philadelphia. Among the acute effects of formaldehyde are irritations of the eyes, the nose, and the throat. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Useful search terms for formaldehyde include “methanal,” “methyl aldehyde,” “methylene oxide.”. 3 Exposure may cause wheezing, asthma attacks and other respiratory symptoms. When exposed to the compound for an appreciable length of time, the throat may feel raw and sore. 74-126 (1976), NIOSH Skin Notation Profiles: Formaldehyde/Formalin, Agency for Toxic Substances Disease Registry (ATSDR)–ToxFAQs: Formaldehyde, ATSDR’s Medical Management Guidelines (MMGs): Formaldehyde, ATSDR Toxicological Profile for Fomaldehyde, Environmental Protection Agency (EPA)–Chemistry Dashboard: Formaldehyde, EPA Acute Exposure Guideline Levels (AEGLs): Formaldehyde, EPA Health Effects Notebook for Hazardous Air Pollutants: Formaldehyde, EPA Sources of Indoor Air Pollution: Formaldehyde, Occupational Safety and Health Agency (OSHA) Chemical Sampling Information: Formaldehyde, OSHA Safety and Health Topics: Formaldehyde, OSHA Hazard Alert: Hair Smoothing Products That Could Release Formaldehyde, National Library of Medicine (NLM)–Haz Map: Formaldehyde, NLM (Household Products Database): Formaldehyde, National Toxicology Program (NTP) Report on Carcinogens (Fourteenth Edition): Formaldehyde, New Jersey Hazardous Substance Fact Sheets: Formaldehyde, Canadian Centre for Occupational Health and Safety (CCOHS): Formaldehyde, European Chemical Agency(ECHA): Formaldehyde, INCHEM (Screening Information Data Set-SIDS): Formaldehyde, International Chemical Safety Cards: Formaldehyde, World Health Organization (WHO) Environmental Health Criteria 89: Formaldehyde, International Agency for Research on Cancer (IARC) Monograph (Vol. Formaldehyde is essential in human metabolism and is required for the synthesis of DNA and amino acids (the building blocks of protein). It is also used as a food preservative and in household products, such as antiseptics, medicines, and cosmetics Effects on the unborn child are more likely to occur if the exposure to formaldehyde causes the mother to become unwell. The following references aid in recognizing formaldehyde hazards in the workplace. In 1980, laboratory studies showed that exposure to formaldehyde could cause nasal cancer in rats. Many studies have been conducted to evaluate the effects of FA during systemic and respiratory exposures in rats. The average quantity of formaldehyde to which a young infant could be exposed to in the first two years of life may be as high as 0.7 – 0.8 mg (see table below). Formaldehyde is released by numerous agents, such as paraformaldehyde, dichlorophene, Dowicil 75 and Dowicil 200 (cis-1-(3-chloroalkyl)-3,5,7-triaza-l-azonia-adamantane chloride), bronopol, Biocide DS 52–49 (1,2-benzoisothiazoline-3-one plus a formaldehyde releaser), and Bakzid (cyclic aminoacetal). Formaldehyde (CH₂O) is a colorless, highly toxic, and flammable gas at room temperature. Some examples of workers at risk of being exposed to formaldehyde include the following: NIOSH recommends that employers use Hierarchy of Controls to prevent injuries. It has also been associated with decreased fertility and adverse reproductive effects. Formaldehyde is an environmental pollutant that is also generated in substantial amounts in the human body during normal metabolism. Formaldehyde is an intermediate in the oxidation (or combustion) of methane, as well as of other carbon compounds, e.g. It is also a cancer hazard. Aside from ALS risk or other nervous system consequences, formaldehyde is a respiratory irritant that causes chest pain, shortness of breath, … Skin Contact. The following resources provide information about occupational exposure to formaldehyde. High levels of exposure may cause some types of cancers. in forest fires, automobile exhaust, and tobacco smoke. 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